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The final proposed mechanism of RBC vasodilation while in the presence of nitrite may be the reduction of nitrite to NO by Hb. Brooks to start with studied the nitrite Hb conversation in 1937 which work was afterwards prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 193